Dr. Flagel's Publications
Colaizzi JM, Flagel SB, Joyner MA, Gearhardt AN, Stewart JL, Paulus MP. Mapping sign-tracking and goal-trackin onto human behaviors. Neuroscience and Biobehavioral Reviews, 111:84-94, April 2020
Campus P, Covelo IR, Kim Y, Parsegian A, Kuhn BN, Lopez SA, Neumaier JF, Ferguson SM, Solberg Woods LC, Sarter M, Flagel SB. The paraventricular thalamus is a critical mediator of top-down control of cuemotivated behavior in rats. eLIFE, 8:e49041, Sept 2019
Flagel SB, Gordon JA, Paulus MP. Editorial: Bridging the gap with computational and translational psychopharmacology. Psychopharmacology, 1-4, July 2019
Kuhn BN, Campus P, Flagel SB. "The Neurobiological Mechanisms Underlying Sign-Tracking Behavior." Sign-tracking and Drug Addiction. Ed. Arthur Tomie and Jonathan Morrow. Maize Books, Chp 3, 2018
Hughson AR, Horvath AP, Holl K, Palmer AA, Solberg Woods LC, Robinson TE, Flagel SB. Incentive salience attribution, "sensation-seeking" and "novelty-seeking" are independent traits in a large sample of male and female heterogeneous stock rats. Sci Rep, 9(1):2351, Feb 2019
Wardle MC, Lopez-Gamundi P, Flagel SB. Measuring appetitive conditioned responses in humans. Physiol Behav, 188:140-150, May 2018
Kuhn BN, Klumpner MS, Covelo IR, Campus P and Flagel SB. Transient inactivation of the paraventricular nucleus of the thalamus enhances cue-induced reinstatement in goal-trackers, but not sign-trackers. Psychopharmacology, 235(4):999-1014, Apr 2018
Joyner MA, Gearhardt AN, Flagel SB. A translational model to assess sign-tracking and goal-tracking behavior in children. Neuropsychopharmacology, 43(1):228-229, Jan 2018.
Mabrouk OS, Han JL, Wong JT, Akil H, Kennedy RT, Flagel SB. In vivo neurochemical profile of selectively bred high-responder and low-responder rats reveals baseline, cocaine- and novelty-evoked differences in monoaminergic systems. ACS Chemical Neuroscience, doi. 10.1021/acschemneuro.7b00294, Nov 2017.
Turner CA, Flagel SB, Blandino P Jr, Watson SJ Jr, Akil H. Utilizing a unique animal model to better understand human temperament. Curr Opin Behav Sci, 14:108-114, April 2017.
García-Fuster MJ, Parsegian A, Watson SJ, Akil H, Flagel SB. Adolescent cocaine exposure enhances goal-tracking behavior and impairs hippocampal cell genesis selectively in adult bred low-responder rats. Psychopharmacology (Berl), 234(8):1293-1305, April 2017.
Flagel SB, Robinson TE. Neurobiological Basis of Individual Variation in Stimulus-Reward Learning. Curr Opin Behav Sci, 13:178-185, February 2017.
Haight JL, Fuller ZL, Fraser K, Flagel SB: A food-predictive cue attributed with incentive salience engages subcortical afferents and efferents of the paraventricular nucleus of the thalamus. Neuroscience, 6;340:135-152, January 2017.
Flagel SB, Chaudhury S, Waselus M, Kelly R, Thompson RT, Watson SJ, Akil H: Genetic background and epigenetic modifications in the core of the nucleus accumbens predict addiction-like behavior in a rat model. Proceedings of the National Academy of Sciences (PNAS), 113(20):E2861-70, May 2016.
Fraser K, Haight J, Gardner E, Flagel SB: Examining the role of dopamine D2 and D3 receptors in Pavlovian Conditioned Approach Behaviors. Behavioral Brain Research, 305:87-99, May 2016.
Morrow JD, Flagel SB: Neuroscience of Resiliency and Vulnerability for Addiction Medicine: From Genes to Behavior. Progress in Brain Research, Neuroscience for Addiction Medicine, 223:3-18, 2016.
Haight JL, Fraser K, Akil H, Flagel SB: The paraventricular nucleus of the thalamus mediates incentive salience attribution to food cues. European Journal of Neuroscience, 42(7):2478-88, Oct 2015
Yager LM, Pitchers KK, Flagel SB, Robinson TE: Individual variation in the motivational and neurobiological effects of an opioid cue. Neuropsychopharmacology, 40(5):1269-77, March 2015.
Pitchers KK, Flagel SB, O’Donnell EG, Solberg-Woods LC, Sarter M, Robinson TE: Individual variation in the propensity to attribute incentive salience to a food cue: influence of sex. Behavioural Brain Research, 278C:462-469, October 2014.
Huys QJM, Tobler PN, Hasler G, Flagel SB: The role of learning-related dopamine signals in addiction vulnerability. In: Diana M, DiChiara G, Spano P (Ed.) Progress in Brain Research, Dopamine. 211:31-77. Elsevier, UK, 2014.
Lesaint F, Sigaud O, Clark JJ, Flagel SB, Khamassi M: Experimental predictions drawn from a computational model fo sign-trackers and goal-trackers. Journal of Physiology – Paris. S0928-4257(14)00024-2, June 2014.
Haight J and Flagel SB: A potential role for the paraventricular nucleus of the thalamus in mediating individual variation in Pavlovian conditioned responses. Special Issue of Frontiers in Behavioral Neuroscience, 8(79):1-10, March 2014.
Lesaint F, Sigaud O, Flagel SB, Robinson TE, Khamassi M: Modelling individual differences in the form of Pavlovian conditioned approach responses: a dual learning systems approach with factored representations. PLoS Computational Biol, 10(2):e1003466, Feb. 2014.
Flagel SB, Waselus M, Clinton SM, Watson SJ, Akil H: Antecedents and consequences of drug abuse in rats selectively bred for high and low response to novelty. NIDA 40th Anniversary Issue of Neuropharmacology, 76:425-436, January 2014.
Parker CC, Chen H, Flagel SB, Geurts AM, Richards JB, Robinson TE, Solberg Woods LC, Palmer AA: Rats are the smart choice: Rationale for a renewed focus on rats in behavioral genetics. NIDA 40th Anniversary Issue of Neuropharmacology, 76:250-258, January 2014.
Waselus M, Flagel SB, Jedynak JP, Akil H, Robinson TE, Watson SJ: Long-term effects of cocaine experience on neuroplasticity in the nucleus accumbens core of addiction-prone rats. Neuroscience, 248C:571-584, June 2013.
*Perez-Sepulveda JA, *Flagel SB, *Garcia-Fuster MJ, Slusky RJ, Aldridge JW, Watson SJ, Akil H: Differential impact of a complex environment on positive affect in an animal model of individual differences in emotionality. Neuroscience, 248C:436-447, June 2013. *shared first authorship.
Fitzpatrick CJ, Golpalakrishnan S, Cogan ES, Yager LM, Meyer PJ, Lovic V, Saunders BT, Parker CC, Gonzales N, Aryee E, Flagel SB, Palmer AA, Robinson TE, Morrow JD: Variation in the form of Pavlovian conditioned approach behavior among outbred male Sprague-Dawley rats from different vendors and colonies: Sign-tracking vs. goal-tracking. PLoS One, 8(10):e75042, Oct. 2013.
Garcia-Fuster MJ, Flagel SB, Mahmood T, Watson, SJ, Akil H: Cocaine withdrawal causes delayed dysregulation of stress genes in the hippocampus. PLoS One, 7(7):e42092, July 2012.
Meyer PJ, Lovic V, Saunders BT, Yager LM, Flagel SB, Morrow JD, Robinson TE: Quantifying individual variation in the propensity to attribute incentive salience to reward cues. PLoS One, 7(6): e38987, June 2012.
Flagel SB, Cameron CM, Pickup KN, Watson SJ, Akil H, Robinson TE: A food predictive cue must be attributed with incentive salience for it to induce c-fos mRNA expression in cortico-striatal-thalamic brain regions. Neuroscience, 196:80-96, Nov 2011.
Garcia-Fuster MJ, Flagel SB, Mahmood T, Mayo L, Thompson RC, Watson, SJ, Akil H: Decreased proliferation of adult hippocampal stem cells during cocaine withdrawal: Possible role of the cell fate regulator FADD. Neuropsychopharmacology, 36(11):2303-17, Oct 2011.
Flagel SB*, Clark JJ*, Robinson TE, Mayo L, Czuj A, Willuhn I, Akers CA, Clinton SM, Phillips PEM†, Akil H†: A selective role for dopamine in stimulus-reward learning. Nature, 469(7328):53-7, Jan 2011. *shared first authorship
Burghardt PB, Flagel SB, Burghardt K, Britton S, Koch L, Watson SJ, Akil H: Risk-assessment and coping strategies segregate with divergent intrinsic aerobic capacity in rats. Neuropsychopharmacology, 36(2):390-401, Jan 2011.
Flagel SB, Robinson TE, Clark JJ, Clinton SM, Watson SJ, Seeman P, Phillips PE, Akil H: An animal model of genetic vulnerability to behavioral disinhibition and responsiveness to reward-related cues: implications for addiction. Neuropsychopharmacology, 35(2): 388-400, Jan 2010.
Robinson TE, Flagel SB: Dissociating the predictive and incentive motivational properties of reward-related cues through the study of individual differences. Biological Psychiatry, 65(10):869-873, May 2009.
Turner CA, Capriles N, Flagel SB, Perez JA, Clinton SM, Watson SJ, Akil H: Neonatal FGF2 alters cocaine self-administration in the adult rat. Pharmacology, Biochemistry and Behavior, 92(1):100-4, March 2009.
Flagel SB, Akil H, Robinson TE: Individual differences in the attribution of incentive salience to reward-related cues: implications for addiction. Neuropharmacology, 56(S1):139-48, June 2009.
Turner CA, Flagel SB, Clinton SM, Akil H, Watson SJ: Cocaine interacts with the novelty-seeking trait to modulate FGFR1 gene expression in the rat. Neuroscience Letters, 446(2-3):105-7, Dec 2008.
Briand LA, Flagel SB, Garcia-Fuster MJ, Watson SJ, Akil H, Sarter M, Robinson TE: Persistent alterations in cognitive function and prefrontal dopamine D2 receptors following extended, but not limited, access to self-administered cocaine. Neuropsychopharmacology 33(12):2969-80, Nov 2008.
Briand LA, Flagel SB, Seeman P, Robinson TE: Cocaine self-administration produces a persistent increase in dopamine D2high receptors. European Neuropsychopharmacology, 18(8):551-6, Aug 2008.
Flagel SB, Watson SJ, Akil H, Robinson TE: Individual differences in the attribution of incentive salience to a reward-related cue: influence on cocaine sensitization. Behavioural Brain Research 186(1):48-56, Jan 2008.
Flagel SB, Robinson TE: Quantifying the psychomotor activating effects of cocaine in the rat. Behavioural Pharmacology 18(4):297-302, July 2007.
Flagel SB, Watson SJ, Robinson TE, Akil H: Individual differences in the propensity to approach signals vs. goals promote different adaptations in the dopamine system of rats. Psychopharmacology (Special Dopamine Issue) 191(3):599-607, April 2007.
Flagel SB, Vázquez DM, Robinson TE: Manipulations during the second, but not the first, week of life increase susceptibility to cocaine self-administration in female rats. Neuropsychopharmacology 28(10): 1741-1751, Oct 2003.
Flagel SB, Neal CR Jr., Vázquez DM, Watson SJ Jr.: Effects of tapering neonatal dexamethasone on rat growth, neurodevelopment, and stress response. American Journal of Physiology: Regulatory, Integrative, Comparative Physiology 282:R55-R63, Jan 2002.
Liberzon I, Abelson JL, Flagel SB, Raz J, Young EA: Neuroendocrine and psychophysiologic responses in PTSD: symptom provocation studies. Neuropsychopharmacology 21(1):40-50, July 1999.
Liberzon I, Lopez J, Vázquez D, Flagel SB, Young EA: Differential regulation of hippocampal glucocorticoid receptors and negative feedback: relevance to post-traumatic stress disorder. Journal of Neuroendocrinology. 11(1): 11-7, Jan 1999.